91069-45-3Relevant academic research and scientific papers
Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
Zhang, Pinglu,Tsuji, Nobuya,Ouyang, Jie,List, Benjamin
, p. 675 - 680 (2021)
In recent years, several organocatalytic asymmetric hydroarylations of activated, electron-poor olefins with activated, electron-rich arenes have been described. In contrast, only a few approaches that can handle unactivated, electronically neutral olefins have been reported and invariably require transition metal catalysts. Here we show how an efficient and highly enantioselective catalytic asymmetric intramolecular hydroarylation of aliphatic and aromatic olefins with indoles can be realized using strong and confined IDPi Br?nsted acid catalysts. This unprecedented transformation is enabled by tertiary carbocation formation and establishes quaternary stereogenic centers in excellent enantioselectivity and with a broad substrate scope that includes an aliphatic iodide, an azide, and an alkyl boronate, which can be further elaborated into bioactive molecules.
Facile Synthesis of 2,6-Dialkylphenols by Cross-Aromatization of Cyclohexanones with Aldehydes Catalyzed by Zirconocene Complexes
Nakano, Tatsuya,Shirai, Hideki,Tamagawa, Hiroshi,Ishii, Yasutaka,Ogawa, Masaya
, p. 5181 - 5183 (2007/10/02)
2,6-Dialkylphenols, which are difficult to prepare by conventional methods, have been conveniently synthesized in one step via zirconocene-catalyzed cross-aromatization of cyclohexanones with aldehydes.
