91075-40-0Relevant academic research and scientific papers
A general synthetic approach to 5-alkyl-2(5H)furanones via 1,3-dipolar cycloaddition
Chiacchio, Ugo,Piperno, Anna,Rescifina, Antonio,Romeo, Giovanni,Uccella, Nicola
, p. 5695 - 5708 (2007/10/03)
[3+2] Cycloaddition methodology provides a general and efficient access to 5-alkyl substituted 2(5H)furanones. The synthetic approach has been exploited towards the synthesis of naturally occurring butenolides.
A SHORT EFFICIENT SYNTHESIS OF 4-HYDROXY-5-(1-HYDROXYALKYL)-γ-BUTYROLACTONES
Scheeren, J.W.,Lange, J.
, p. 1609 - 1612 (2007/10/02)
The cycloaddition of α,β-epoxyaldehydes or ketones (2) with the ketene acetal MeHC=C(OMe)2 (1) gives epoxyoxetanes (3) in high yields.Without isolation they can be transformed into 4-hydroxy-5-(1-hydroxyalkyl)-γ-butyrolactones (6) via the epoxy esters 4 and trihydroxy esters (5).The lactones 6 appear to be valuable precursors for the synthesis of 5-(1-hydroxyalkyl)-3-methyl-2-5H-furanones (7) and 3-methyl-5-ylidene-2-5H-furanones (8)
