91088-87-8Relevant academic research and scientific papers
A simple and convenient procedure for lithiation and side-chain substitution of 2-alkyl-4-(methylthio)quinazolines and 2-alkyl-4- methoxyquinazolines
Smith, Keith,El-Hiti, Gamal A.,Hegazy, Amany S.
, p. 2951 - 2961 (2005)
2-Methyl-4-(methylthio)quinazoline has been lithiated, in the 2-methyl group, with n-BuLi at -78 °C in THF. The lithium reagent thus obtained reacts with a variety of electrophiles (iodomethane, iodoethane, D2O, benzaldehyde, 4-anisaldehyde, he
