91091-08-6Relevant academic research and scientific papers
Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues
Robin, Aelig,Julienne, Karine,Meslin, Jean-Claude,Deniaud, David
, p. 634 - 643 (2007/10/03)
A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
