91103-22-9

Upstream product

• 91103-06-9 (6S)-3-(2-Furyl)-6-isopropyl-2,5-morpholindion 
• 91103-02-5 Furan-2-yl-(2-hydroxy-3-methyl-butyrylamino)-acetic acid 
• 91102-98-6 N-(2-Acetoxy-3-methylbutanoyl)-2-(2-furyl)glycin 
• 17119-54-9 DL-2-amino-2-(furan-2-yl)acetic acid 
• 5469-33-0 cyclohexylmethyl iodide 
• 91103-10-5 (6S)-3-(2-Furyl)-3,6-dihydro-6-isopropyl-5-methoxy-1,4-oxazin-2-on 

Relevant academic research and scientific papers

Asymmetric Synthesis via Heterocyclic Intermediates, XXIII. - Studies on the Enantioselective Synthesis of α-Alkyl-α-(2-furyl)glycines by Alkylation of 3-(2-Furyl)-3,6-dihydro-2H-1,4-oxazin-2-ones Chirally Substituted at C-6

3-(2-Furyl)-3,6-dihydro-2H-1,4-oxazin-2-ones 10 and 11 are synthesized from DL-(2-furyl)glycine and 2-hydroxyalkanoic acids 4.The heterocycles 10 and 11 contain an endocyclic chiral center at C-6.Their potassium derivatives 12 (obtained with potassium tert-butoxide) react with alkyl halides R2-X in good chemical yields and with d.e. values (d.e. = asymmetric induction) from 50 to 95percent to give adducts 13.These on hydrolysis are cleaved to yield α-alkyl-α-(2-furyl)glycines 17 and 2-hydroxyalkanoic acids 4.