91105-99-6

Upstream product

• 108-43-0 3-monochlorophenol 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 

Downstream Products

• 851341-60-1 [2-chloro-6-(methoxymethoxy)phenyl]trimethylsilane 
• 5106-98-9 4-chlorosalicylic acid 
• 56961-31-0 6-chloro-2-hydroxybenzoic acid 
• 55736-04-4 6’-chloro-2’-hydroxyacetophenone 
• 1263427-05-9 tert-butyl 5-chloro-4-phenyl-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate 
• 1263427-06-0 5-chloro-4-phenylspiro[chromene-2,4'-piperidine] 
• 1263427-07-1 tert-butyl {5-[2-(5-chloro-4-phenyl-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetate 
• 1263426-57-8 {5-[2-(5-chloro-4-phenyl-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-1,3-thiazol-5-yl]-2H-tetrazol-2-yl}acetic acid 
• 1599432-42-4 C₁₄H₂₀BClO₄ 
• 858854-82-7 3-chloro-2-iodo-phenol 

Relevant academic research and scientific papers

Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary

The atropo-selective coupling of in situ generated arynes and aryllithiums bearing various chiral auxiliaries ortho to lithium (tert-butylsulfoxide, para-tolylsulfoxide, tartrate-derived chiral diethers and oxazolines) is described. Chiral oxazolines showed the best results in terms of yields of coupling products. Different reaction parameters like the nature of the aryne precursor, the oxazoline, the alkyllithium base or the solvent revealed to be crucial for obtaining good yields and for diastereoselection.

NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and

NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE

Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desat- urase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS

The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

The site-selective functionalization of halogen-bearing phenols: An exercise in diversity-oriented organometallic synthesis

The organometallic approach to diversity-oriented organic synthesis was subjected to a further test, this time in the phenol series. The model compounds selected were 2,3,6-trifluorophenol, the three isomers of (trifluoromethoxy) phenol and the three isomers of chlorophenol. A combination of optionally site selective metalations and protective group-controlled metalations enabled the selective generation of several isomeric intermediates in each case and their subsequent conversion into functionalized derivatives, in particular hydroxybenzoic acids.