91106-60-4Relevant academic research and scientific papers
Syntheses of (+/-)-Tetrahydropalmatine and Spirobenzylisoquinolines by Thermolysis of Benzocyclobutene Derivatives
Kametani, Tetsuji,Yukawa, Hirotaka,Suzuki, Yukio,Honda, Toshio
, p. 2151 - 2154 (2007/10/02)
The tetrahydroprotoberberine alkaloid, (+/-)-tetrahydropalmatine (1) was synthesized by heating the 1-benzocyclobutenyl-3,4-dihydroisoquinoline (16), followed by reduction of the dehydro compound (20) with sodium borohydride.Ochotensine type spirobenzylis
SYNTHESIS OF 2,3,9,10-TETRAOXYGENATED PROTOBERBERINE ALKALOID, TETRAHYDROPALMATINE
Kametani, Tetsuji,Yukawa, Hirotaka,Suzuki, Yukio,Yamaguchi, Ryoji,Honda, Toshio
, p. 1067 - 1069 (2007/10/02)
Tetrahydropalmatine (15) was synthesized from the 3,4-dihydroisoquinoline derivative (13) by thermal electrocyclic reaction and subsequent reduction.An intermolecular Diels-Alder type reaction of the benzocyclobutane (6) with the 3,4-dihydroisoquinoline afforded the 13-cyanoprotoberberine (9) regioselectively.
