911108-83-3Relevant academic research and scientific papers
Rational design of central selective acetylcholinesterase inhibitors by means of a "bio-oxidisable prodrug" strategy
Bohn, Pierre,Le Fur, Nicolas,Hagues, Guillaume,Costentin, Jean,Torquet, Nicolas,Papamicael, Cyril,Marsais, Francis,Levacher, Vincent
experimental part, p. 2612 - 2618 (2009/10/30)
This work deals with the design of a "bio-oxidisable prodrug" strategy for the development of new central selective acetylcholinesterase inhibitors. This prodrug approach is expected to reduce peripheral anticholinesterase activity responsible for various
NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS
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Page/Page column 45, (2008/06/13)
The invention is related to compound which comprises at least one radical C=Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C=Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.
