911123-01-8Relevant academic research and scientific papers
Alcaligenes faecalis penicillin G acylase-catalyzed enantioselective acylation of dl-phenylalanine and derivatives in aqueous medium
Gong, Xiangyu,Su, Erzheng,Wang, Pixiang,Wei, Dongzhi
supporting information; experimental part, p. 5398 - 5402 (2011/10/19)
A new strategy based on enantioselective acylation properties of relatively unknown penicillin G acylase from Alcaligenes faecalis has been developed for the production of pharmacologically interesting enantiomerically pure d-phenylalanine. In order to get high reaction rate and enantioselectivity, two key factors (pH and temperature) and eight different acyl donors were optimized, and the optimal acylation reaction was carried out at pH 10, 35 °C, using phenylacetamide as the acyl donor. This enantioselective acylating method is also illustrated by the effective production of five different p-substituted phenylalanine derivatives in enantiopure.
Expanding the scope of biocatalysis: Oxidative biotransformations on solid-supported substrates
Brooks, Sarah J.,Coulombel, Lydie,Ahuja, Disha,Clark, Douglas S.,Dordick, Jonathan S.
experimental part, p. 1517 - 1525 (2009/09/07)
Oxidative biocatalytic reactions were performed on solid-supported substrates, thus expanding the repertoire of biotransformations that can be carried out on the solid phase. Various phenylacetic and benzoic acid analogues were attached to controlled pore
