91119-28-7

Upstream product

• 875-51-4 4-Bromo-2-nitroaniline 
• 1020369-71-4 2-(2-(2-nitro-bromophenyl)hydrazono)propionic acid ethyl ester 
• 100032-79-9 (4-bromo-2-nitrophenyl)hydrazine hydrochloride 

Downstream Products

• 1579995-22-4 5-(3-acetamidophenyl)-7-nitro-1H-indole-2-carboxylic acid 
• 1579995-23-5 5-((3-methoxyphenyl)amino)-7-nitro-1H-indole-2-carboxylic acid 
• 1579995-27-9 ethyl 5-((3-methoxyphenyl)amino)-7-nitro-1H-indole-2-carboxylate 
• 1579995-26-8 ethyl 5-(3-acetamidophenyl)-7-nitro-1H-indole-2-carboxylate 
• 91119-16-3 7-Amino-5-bromo-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

N-acyl sulfamide FBPase inhibitor, preparation method thereof, drug composition and application

The invention discloses an N-acryl sulfamide FBPase inhibitor of a novel structure, and a preparation method thereof, a drug composition and an application, and particularly relates to an N-acryl sulfamide FBPase inhibitor shown in the formula I, a salt thereof for medicine, a preparation method, a composition comprising one or more compounds, an application of the compound in preparing the FBPase inhibitor or a drug for treating FBPase-related diseases, and an application in preparing a drug for preventing and/or treating diabetes. The formula is shown in the description.

Design, synthesis and biological evaluation of 7-nitro-1H-indole-2- carboxylic acid derivatives as allosteric inhibitors of fructose-1,6- bisphosphatase

A series of novel indole derivatives was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase). Extensive structure-activity relationships were conducted and led to a potent FBPase inhibitor 3.9 with an IC50 of 0.99 μM. The binding mode of this series of indoles was predicted using CDOCKER algorithm. The results of this research will shed light on the further design and optimization of novel small molecules as FBPase inhibitors.