911213-96-2Relevant academic research and scientific papers
Asymmetric aza-Wittig reactions: Enantioselective synthesis of β-quaternary azacycles
Lertpibulpanya, Duanpen,Marsden, Stephen P.,Rodriguez-Garda, Ignacio,Kilner, Colin A.
, p. 5000 - 5002 (2006)
A hindrance no more: The direct asymmetric synthesis of nitrogen heterocycles containing β-quaternary stereocenters, widely found for example in alkaloids, is highly challenging. The novel approach shown exploits the desymmetrization of prochiral diketo azides to unmask the asymmetric quaternary center, and represents the first reported examples of the asymmetric aza-Wittig reaction. (Chemical Equation Presented).
