911217-76-0Relevant academic research and scientific papers
Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis
Wyatt, Emma E.,Galloway, Warren R. J. D.,Thomas, Gemma L.,Welch, Martin,Loiseleur, Olivier,Plowright, Alleyn T.,Spring, David R.
, p. 4962 - 4964 (2008)
The screening of a diversity-oriented synthesis library followed by structure-activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureus dihydrofolate reductase. The Royal Society of Chemistry.
Skeletal diversity construction via a branching synthetic strategy
Wyatt, Emma E.,Fergus, Suzanne,Galloway, Warren R. J. D.,Bender, Andreas,Fox, David J.,Plowright, Alleyn T.,Jessiman, Alan S.,Welch, Martin,Spring, David R.
, p. 3296 - 3298 (2008/09/19)
A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated. The Royal Society of Chemistry 2006.
