91127-04-7Relevant academic research and scientific papers
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors
Wan, Yichao,Wang, Junhua,Sun, Feng'E,Chen, Minglu,Hou, Xuben,Fang, Hao
, p. 7685 - 7693 (2015/12/20)
Anti-apoptotic proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, are potential targets for cancer treatment. In the studies, a series of pyrrolidine derivatives were developed as potent Mcl-1 inhibitors. The preliminary biological studies suggested that most of target compounds exhibit good abilities for targeting Mcl-1 protein. Among them, compound 21 (Ki = 0.53 μM) exhibited equal inhibitory activities towards Mcl-1 protein compared to positive control gossypol (Ki = 0.39 μM). This compound also possessed good antiproliferative activities against MDA-MB-231 and PC-3 cancer cells.
COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
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Page/Page column 74, (2008/06/13)
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.
Vitamin K Dependent Carboxylation: Synthesis and Biological Properties of Tetrazolyl Analogues of Pentapeptidic Substrates
Dubois, Jooelle,Bory, Sonia,Gaudry, Michel,Marquet, Andree
, p. 1230 - 1233 (2007/10/02)
The pentapeptides Phe-Leu-X-Glu-Val and Phe-Leu-X-X-Val, where X= 4-(5H-tetrazolyl)-2-aminobutyric acid (tetrazolyl analogue of glutamic acid), were synthesized by addition of tri-n-butyltin azide to the corresponding nitrile-containing peptides.These tet
