911281-79-3Relevant academic research and scientific papers
Enzyme mimics for Michael additions with novel proton transport groups
Simon, Luis,Muniz, Francisco M.,Saez, Silvia,Raposo, Cesar,Moran, Joaquin R.
, p. 2397 - 2403 (2008)
Molecular receptors with an enzyme-like behavior in the Michael addition of pyrrolidine to an α,β-unsaturated lactam have been designed. Catalytic activities are discussed and related to the substrate association constants. Chiral assistance of enantiomerically pure receptors was also investigated. One of the receptors shows a 4:1 enantiomeric ratio (60% ee) for the addition of pyrrolidine and 3-pyrroline. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
