911300-75-9Relevant articles and documents
Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: The role of extravascular transport
Hay, Michael P.,Hicks, Kevin O.,Pruijn, Frederik B.,Pchalek, Karin,Siim, Bronwyn G.,Wilson, William R.,Denny, William A.
, p. 6392 - 6404 (2008/04/05)
Pharmacokinetic/pharmacodynamic (PK/PD) modeling has shown the antitumor activity of tirapazamine (TPZ), a bioreductive hypoxia-selective cytotoxin, to be limited by poor penetration through hypoxic tumor tissue. We have prepared a series of 1,2,4-benzotr