911302-20-0

Basic information

• Product Name: 2-(2H)-4-chloroanisole
• Synonyms: 2-(2H)-4-chloroanisole
• CAS NO: 911302-20-0
• Molecular Weight: 143.577
• Mol File: 911302-20-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2H)-4-chloroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2H)-4-chloroanisole(911302-20-0)
• EPA Substance Registry System: 2-(2H)-4-chloroanisole(911302-20-0)

Safety Data

• Hazardous Substances Data: 911302-20-0(Hazardous Substances Data)

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 60633-25-2 2-bromo-4-chloroanisole 

Downstream Products

• 116467-75-5 2-(2H)-4-chlorophenol 
• 911302-21-1 1-chloro-3,5-dideutero-4-methoxybenzene 
• 60633-25-2 2-bromo-4-chloroanisole 

Relevant articles and documents

Mechanistic study on iodine-catalyzed aromatic bromination of aryl ethers by N-Bromosuccinimide

Although iodine-catalyzed reaction has rapid advances in recent years, examples on iodine-catalyzed bromination are rare and the mechanism of these reactions remains unclear. Herein, we reported an I2-catalyzed aromatic bromination of aryl ethers by NBS and presented the details of the mechanistic study including kinetic study and the study of kinetic isotope effects. The study revealed that the reaction was actually catalyzed by IBr formed in the induction period, and the rate-determining step was the HBr-elimination of the Wheland intermediate assisted by IBr.

Decoupling deprotonation from metalation: Thia-fries rearrangement

(Chemical Equation Presented) Label-enabled: Studies with 2H-, 18O-, and 34S-labeled aryl triflates show that lithium diisopropylamide-mediated thia-Fries rearrangement proceeds through an irreversible ortho deprotonation (see scheme; DIPA = diisopropylamine, LDA = lithium diisopropylamide). In contrast, ortho metalation results exclusively in the generation of a benzyne.