911319-41-0

Upstream product

• 105228-46-4 (5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1352147-50-2 (3R,5R,6S)-benzyl 3-((3-bromo-4-methoxyphenyl)((tert-butyldimethylsilyl) oxy)methyl)-2-oxo5,6-diphenylmorpholine-4-carboxylate 
• 1352147-51-3 (3R,5R,6S)-3-((R)-(3-bromo-4-methoxyphenyl)((tert-butyldimethylsilyl)oxy)methyl)-5,6-diphenylmorpholin-2-one 
• 1352147-49-9 (3R,5R,6S)-3-((S)-(3-bromo-4-methoxyphenyl)((tert-butyldimethylsilyl)oxy)methyl)-5,6-diphenylmorpholin-2-one 
• 1352147-55-7 (2R,3S)-methyl 2-amino-3-(3-bromo-4-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)propanoate 
• 1352147-54-6 (2R,3S)-methyl 3-(3-bromo-4-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)-2-(methylamino)propanoate 
• 1352147-53-5 (2R,3S)-methyl 3-(3-bromo-4-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)-2-(((1R,2S)-2-hydroxy 1,2diphenylethyl)(methyl)amino)propanoate 
• 1352147-52-4 (2R,3S)-methyl 3-(3-bromo-4-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)-2-(((1R,2S)-2-hydroxy-1,2-diphenylethyl)amino)propanoate 
• 911319-43-2 (3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester 
• 911319-64-7 (2R,3R)-2-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethylamino)-3-(6-methoxy-quinolin-4-yl)-3-triethylsilanyloxy-propionic acid methyl ester 
• 911319-63-6 (3R,5R,6S)-3-[(R)-(6-Methoxy-quinolin-4-yl)-triethylsilanyloxy-methyl]-5,6-diphenyl-morpholin-2-one 
• 911319-42-1 (3R,5R,6S)-3-[(R)-Hydroxy-(6-methoxy-quinolin-4-yl)-methyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthetic studies on quinine: Quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation

7-Hydroxy-quinine was synthesized by an asymmetric aldol reaction that establishes the C8 and C9 stereochemistry, followed by construction of the 3-vinyl-quinuclidine azabicyclo[2.2.2]octane by C3-C4 ring closure using an intramolecular palladium-mediated

Synthetic studies toward MPC1001: Preparation of a β-hydroxyl-tyrosine derivative

A procedure for the asymmetric synthesis of a novel β-hydroxy-α- amino acid derivative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol