91133-72-1

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-acetamido-2-methyl-benzoate serves as a crucial intermediate in the synthesis of various drugs, particularly those intended for pain relief and reduction of inflammation. Its chemical structure allows for the development of medications that can effectively address these health concerns.
Used in Fragrance and Flavor Production:
Leveraging its aromatic properties, methyl 5-acetamido-2-methyl-benzoate is utilized in the creation of fragrances and flavors, adding to the sensory experience of various consumer products.
Safety Considerations:
Due to its potential to cause skin and eye irritation, methyl 5-acetamido-2-methyl-benzoate requires careful handling and adherence to safety guidelines to mitigate any adverse effects on users and handlers.

InChI:InChI=1/C11H13NO3/c1-7-4-5-9(12-8(2)13)6-10(7)11(14)15-3/h4-6H,1-3H3,(H,12,13)

Upstream product

• 103204-70-2 5-acetylamino-2-methyl-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 77324-87-9 methyl 2-methyl-5-nitrobenzoate 
• 587-48-4 3-acetylaminobenzoic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 863885-69-2 methyl 5-acetamido-2-methyl-4-nitrobenzoate 

Relevant academic research and scientific papers

SPIRO[3H-INDOLE-3,2′-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, R7, A, D, E, F, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

Iron-Catalyzed Ortho C-H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand

Iron-catalyzed C-H functionalization of aromatics has attracted widespread attention from chemists in recent years, while the requirement of an elaborate directing group on the substrate has so far hampered the use of simple aromatic carbonyl compounds such as benzoic acid and ketones, much reducing its synthetic utility. We describe here a combination of a mildly reactive methylaluminum reagent and a new tridentate phosphine ligand for metal catalysis, 4-(bis(2-(diphenylphosphanyl)phenyl)phosphanyl)-N,N-dimethylaniline (Me2N-TP), that allows us to convert an ortho C-H bond to a C-CH3 bond in aromatics and heteroaromatics bearing simple carbonyl groups under mild oxidative conditions. The reaction is powerful enough to methylate all four ortho C-H bonds in benzophenone. The reaction tolerates a variety of functional groups, such as boronic ester, halide, sulfide, heterocycles, and enolizable ketones.

VIRAL POLYMERASE INHIBITORS

An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.