911358-54-8Relevant academic research and scientific papers
Sulfamides as novel histone deacetylase inhibitors
Wahhab, Amal,Smil, David,Ajamian, Alain,Allan, Martin,Chantigny, Yves,Therrien, Eric,Nguyen, Natalie,Manku, Sukhdev,Leit, Silvana,Rahil, Jubrail,Petschner, Andrea J.,Lu, Ai-Hua,Nicolescu, Alina,Lefebvre, Sylvain,Montcalm, Samuel,Fournel, Marielle,Yan, Theresa P.,Li, Zuomei,Besterman, Jeffrey M.,Deziel, Robert
scheme or table, p. 336 - 340 (2011/03/18)
The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors.
SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 74, (2010/11/29)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 52; 53, (2010/11/24)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
