911359-29-0

Basic information

• Product Name: (S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid
• Synonyms: (S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid
• CAS NO: 911359-29-0
• Molecular Weight: 292.315
• Mol File: 911359-29-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid(911359-29-0)
• EPA Substance Registry System: (S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid(911359-29-0)

Safety Data

• Hazardous Substances Data: 911359-29-0(Hazardous Substances Data)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 22951-96-8 L-3-(2-thienyl)alanine 

Downstream Products

• 911359-30-3 (S)-methyl 2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoate 

Relevant articles and documents

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

In an effort to identify HDAC isoform selective inhibitors, we designed and synthesized novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs. The observed selectivity and potency (IC50 values 10-200 nM against HDAC6) is markedly dependent on the absolute configuration of the chiral moiety, and suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.