911370-03-1

Basic information

• Product Name: Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-chloro-8-(2,4-difluorophenyl)-2-(methylthio)-
• CAS NO: 911370-03-1
• Molecular Formula: C14H8ClF2N3OS
• Molecular Weight: 339.753
• Mol File: 911370-03-1.mol

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-chloro-8-(2,4-difluorophenyl)-2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-chloro-8-(2,4-difluorophenyl)-2-(methylthio)-(911370-03-1)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-chloro-8-(2,4-difluorophenyl)-2-(methylthio)-(911370-03-1)

Safety Data

• Hazardous Substances Data: 911370-03-1(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 88738-78-7 bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate 
• 33097-11-9 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 
• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 1979-98-2 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) 

Downstream Products

• 911370-06-4 4-chloro-8-(2,4-difluorophenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 911370-09-7 4-chloro-8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.

An improved and highly convergent synthesis of 4-substituted-pyrido[2,3-d]pyrimidin-7-ones

A novel and efficient route to 4-substituted-pyrido[2,3-d]pyrimidin-7-ones is described resulting in arrays of compounds with biological interest.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.

PROCESS FOR PREPARING PYRIDO[2,3-D]PYRIMIDIN-7-ONE AND 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE DERIVATIVES

The present invention is directed to a novel method of preparing of 2,4,8- trisubstituted pyrido[2,3-d]pyrimidin-7-one pharmacophores of Formula (II) or (Ha) wherein GHs CH2 Or NH: G2 is CH or nitrogen; Rx is chloro, bromo, iodo, or O-S(O)