911370-07-5

Upstream product

• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 1979-98-2 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) 
• 33097-11-9 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 
• 5509-65-9 2,6-difluoroaniline 
• 444605-13-4 4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde 
• 911110-48-0 4-chloro-2-methylsulfanyl-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one 

Downstream Products

• 929213-78-5 2-(2-amino-ethylamino)-4-chloro-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one 
• 911370-10-0 4-chloro-8-(2,6-difluorophenyl)-2-{[2-hydroxy-1-(hydroxy-methyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one 
• 929213-79-6 N-{2-[4-chloro-8-(2,6-difluoro-phenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-ethyl}-methanesulfonamide 
• 911370-41-7 4-(4-methylsulfanylphenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one 

Relevant academic research and scientific papers

Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Chemoselectivity of chlorine versus methylthio (-SCH3), methylsulfinyl (-SOCH3), or methylsulfonyl [-S(O)2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studi

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.

An improved and highly convergent synthesis of 4-substituted-pyrido[2,3-d]pyrimidin-7-ones

A novel and efficient route to 4-substituted-pyrido[2,3-d]pyrimidin-7-ones is described resulting in arrays of compounds with biological interest.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors.

PROCESS FOR PREPARING PYRIDO[2,3-D]PYRIMIDIN-7-ONE AND 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE DERIVATIVES

The present invention is directed to a novel method of preparing of 2,4,8- trisubstituted pyrido[2,3-d]pyrimidin-7-one pharmacophores of Formula (II) or (Ha) wherein GHs CH2 Or NH: G2 is CH or nitrogen; Rx is chloro, bromo, iodo, or O-S(O)