911395-35-2Relevant academic research and scientific papers
Solution-, solid-phase, and fluorous synthesis of β,β- difluorinated cyclic quaternary a-amino acid derivatives: A comparative study
Fustero, Santos,Sanchez-Rosello, Maria,Rodrigo, Vanessa,Sanz-Cervera, Juan F.,Piera, Julio,Simon-Fuentes, Antonio,Del Pozo, Carlos
supporting information; experimental part, p. 7019 - 7029 (2009/08/07)
The diastereoselective synthesis of cyclic β,β-difluorinated α-amino acid derivatives bearing a quaternary stereocenter is described. The process relies on the chemo- and diastereoselective addition of allylic organometallic reagents to fluorinated αimino
Asymmetric synthesis of new β,β-difluorinated cyclic quaternary α-amino acid derivatives
Fustero, Santos,Sanchez-Rosello, Maria,Rodrigo, Vanessa,Del Pozo, Carlos,Sanz-Cervera, Juan F.,Simon, Antonio
, p. 4129 - 4132 (2007/10/03)
The synthesis of new β,β-difluorinated cyclic quaternary α-amino acid derivatives 1 in which a ring-closing metathesis reaction (RCM) constitutes the key step is described. The approach employs imidoyl chlorides 3 as fluorinated building blocks, and the o
