EC144, also known as 5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol, is a potent inhibitor of the heat shock protein 90 (HSP90). It has been found to be effective in suppressing tumor growth and has potential applications in various industries.
911397-80-3
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Basic information
- Product Name: EC144
- Synonyms: EC144;5-[2-AMino-4-chloro-7-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-7H-pyrrolo[2,3-d]pyriMidin-5-yl]-2-Methyl-4-pentyn-2-ol
- CAS NO:911397-80-3
- Molecular Formula: C21H24ClN5O2
- Molecular Weight: 413.90056
- EINECS: N/A
- Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 911397-80-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 674.1±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.29±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 14.52±0.29(Predicted)
- CAS DataBase Reference: EC144(CAS DataBase Reference)
- NIST Chemistry Reference: EC144(911397-80-3)
- EPA Substance Registry System: EC144(911397-80-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 911397-80-3(Hazardous Substances Data)
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911397-80-3 Usage
Uses
Used in Pharmaceutical Industry:EC144 is used as an anticancer agent for its ability to inhibit the heat shock protein 90, which plays a crucial role in tumor growth and progression. By targeting HSP90, EC144 can effectively suppress tumor growth and may have potential synergistic effects when combined with other chemotherapeutic drugs.
Used in Drug Development:
EC144 is used as a lead compound in drug development for its potential to treat various types of cancer. Its potent inhibitory effect on HSP90 makes it a promising candidate for further research and development into a novel anticancer drug.
Used in Cancer Research:
EC144 is used as a research tool in cancer research to study the role of heat shock protein 90 in tumor growth and progression. Understanding the mechanism of action of EC144 can help researchers develop new strategies for cancer treatment and prevention.
Used in Drug Delivery Systems:
EC144 can be incorporated into drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. Various organic and metallic nanoparticles can be employed as carriers for EC144, enhancing its effectiveness in treating cancer.
Used in Clinical Trials:
EC144 is used in clinical trials to evaluate its safety, efficacy, and potential side effects in treating cancer patients. These trials can provide valuable information on the optimal dosage, administration, and potential benefits of EC144 as an anticancer agent.
Check Digit Verification of cas no
The CAS Registry Mumber 911397-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,1,3,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.Calculate Digit Verification of CAS Registry Number 911397-80:
(8*9)+(7*1)+(6*1)+(5*3)+(4*9)+(3*7)+(2*8)+(1*0)=173
173 % 10 = 3
So 911397-80-3 is a valid CAS Registry Number.
911397-80-3Upstream product
911397-80-3Downstream Products
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EC144
