911411-42-2

Basic information

• Product Name: (1S)-1-phenyl-N-[(E)-2,2,2-trifluoroethylidene]ethanamine
• Synonyms: (1S)-1-phenyl-N-[(E)-2,2,2-trifluoroethylidene]ethanamine
• CAS NO: 911411-42-2
• Molecular Weight: 201.191
• Mol File: 911411-42-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1S)-1-phenyl-N-[(E)-2,2,2-trifluoroethylidene]ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1-phenyl-N-[(E)-2,2,2-trifluoroethylidene]ethanamine(911411-42-2)
• EPA Substance Registry System: (1S)-1-phenyl-N-[(E)-2,2,2-trifluoroethylidene]ethanamine(911411-42-2)

Safety Data

• Hazardous Substances Data: 911411-42-2(Hazardous Substances Data)

Upstream product

• 431-46-9 2,2,2-trifluoro-1-methoxy-ethanol 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 198273-23-3 (3R,4R)-3-Benzyloxy-1-((S)-1-phenyl-ethyl)-4-trifluoromethyl-azetidin-2-one 
• 198273-26-6 (2S,3S)-2-Benzyloxy-4,4,4-trifluoro-3-((S)-1-phenyl-ethylamino)-butyric acid methyl ester 
• 198273-25-5 (2R,3R)-methyl 2-(benzyloxy)-4,4,4-trifluoro-3-((S)-1-phenylethyl-amino)butanoate 

Relevant articles and documents

Diastereoselective Friedel-Crafts reaction of α-trifluoromethyl imines derived from chiral amines

The Friedel-Crafts reactions of chiral N-(2,2,2-trifluoroethylidene)-1-arylethylamines 1a and 1b with various electron-rich aromatic compounds were examined. The reactions proceeded readily at room temperature in the presence of BF3·Et2O. Substituted products 2-12 were obtained in low to very high stereoselectivities (up to 100% d.e.). The absolute configuration of compound 12 was determined by X-ray analysis. Moreover, the chiral auxiliary from compounds 3 and 12 was selectively removed by palladium-catalyzed hydrogenolysis.

SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE

This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating inflammation-related disorders, including pain.