911412-23-2Relevant academic research and scientific papers
Discovery of clinical candidate GSK1842799 As a selective S1P1 receptor agonist (prodrug) for multiple sclerosis
Deng, Hongfeng,Bernier, Sylvie G.,Doyle, Elisabeth,Lorusso, Jeanine,Morgan, Barry A.,Westlin, William F.,Evindar, Ghotas
, p. 942 - 947 (2013)
To develop effective oral treatment for multiple sclerosis (MS), we discovered a series of alkyl-substituted biaryl amino alcohols as selective S1P1 modulators. One exemplar is (S)-2-amino-2-(5-(4-(octyloxy)-3- (trifluoromethyl)phenyl)-1,3,4-th
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists
Evindar, Ghotas,Bernier, Sylvie G.,Doyle, Elisabeth,Kavarana, Malcolm J.,Satz, Alexander L.,Lorusso, Jeanine,Blanchette, Heather S.,Saha, Ashis K.,Hannig, Gerhard,Morgan, Barry A.,Westlin, William F.
scheme or table, p. 2520 - 2524 (2010/07/02)
In pursuit of a potent and highly selective sphingosine-1-phosphate receptor agonists with an improved in vivo conversion of the precursor to the active phospho-drug, we have utilized previously reported phenylamide and phenylimidazole scaffolds to identi
