911434-91-8Relevant articles and documents
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48
Wan, Zhao-Kui,Lee, Jinbo,Xu, Weixin,Erbe, David V.,Joseph-McCarthy, Diane,Follows, Bruce C.,Zhang, Yan-Ling
, p. 4941 - 4945 (2007/10/03)
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PT