91144-06-8

Usage

Uses

Used in Pharmaceutical Industry:
(2,4-dimethoxy-phenyl)-pyruvic acid is used as an active pharmaceutical ingredient for its potential therapeutic applications in treating various diseases. Its antioxidant and anti-inflammatory properties make it a valuable compound in the development of medications targeting a range of conditions.
Used in Organic Synthesis:
In the field of organic synthesis, (2,4-dimethoxy-phenyl)-pyruvic acid is used as a key intermediate compound for the synthesis of various organic molecules. Its unique structure allows it to be a versatile building block in creating complex organic compounds.
Used in Medicinal Chemistry:
(2,4-dimethoxy-phenyl)-pyruvic acid is utilized in medicinal chemistry as a starting material for the development of new drugs. Its potential anti-cancer and neuroprotective activities make it an attractive candidate for the creation of novel therapeutic agents.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its inherent properties, (2,4-dimethoxy-phenyl)-pyruvic acid is used as a natural antioxidant and anti-inflammatory agent. It can be incorporated into formulations for health supplements or topical applications to provide these benefits.
Used in Cancer Research:
(2,4-dimethoxy-phenyl)-pyruvic acid is used in cancer research as a potential anti-cancer agent. Its ability to target and inhibit cancer cells makes it a subject of interest for developing new cancer treatments.
Used in Neuroprotective Studies:
In the realm of neuroprotection, (2,4-dimethoxy-phenyl)-pyruvic acid is used in studies aimed at understanding and treating neurodegenerative diseases. Its neuroprotective activities suggest potential benefits in preserving neuronal health and function.

Upstream product

• 118555-99-0 (Z)-4-(2,4-dimethoxybenzylidene)-2-phenyl-4H-oxazol-5-one 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Downstream Products

• 7051-14-1 1-isopropyl-2,4-dimethyloxybenzene 
• 139109-55-0 3-(2,4-dimethoxy-phenyl)-2-hydroxyimino-propionic acid 

Relevant academic research and scientific papers

An expedient synthesis of isopropyl anisoles and veratroles

Isopropyl-substituted anisoles and veratroles were obtained in high yields (89-93%) on the aqueous work-up of the reaction of 3-(methoxyphenyl)-2-oxopropanoic acids with iodomethane and potassium hydroxide in dimethyl sulfoxide.

Biosynthesis of the A/B/C/D-Ring System of the Rotenoid Amorphigenin by Amorpha fruticosa Seedlings

With phenylalanine as the starting point, the biosynthesis of the characteristic rotenoid A/B/C/D-ring system of amorphigenin is studied using Amorpha fruticosa seedlings.The course of the biosynthesis can be divided into four phases represented by the bordered and interconnecting Schemes 1, 3, 6 and 7 which summarise the Chalcone-Flavanone Phase, the Flavanone-Isoflavone Phase, the Hydroxylation/Methoxylation Phase and the Rotenoid Phase.By using an INADEQUATE NMR experiment involving the administration of acetate, the type of folding forming ring-D isdemonstrated by 13C-13C coupling and is interpreted as involving a polyketide containing a glutaconate segment which cyclises by a Claisen condensation.The resulting chalcone is cyclised, enzymically and stereospecifically, to 4',7-dihydroxyflavanone.The latter flavanone undergoes aryl migration, in a manner similar to that found in isoflavone biosynthesis, to give 7-hydroxy-4'-methoxyisoflavone.Possible mechanisms for the flavanone-isoflavone rearrangement are discussed, including a proposal that the initiating step involves attack on ring-A and is similar to the first stage of the aromatic hydroxylation of tyrosine to dopa.Although possessing no 4'-hydroxy group in ring-A, the mechanism is also applicable to the recently discovered rotenoids of the Boerhaavia and Iris type, and it provides an explanation for the biogenesis of natural spirobenzocyclobutanes from dihydroeucominoids.Six suitably substituted isoflavonoids labelled with 13C or 3H are synthesized and are used to show that the next hydroxylation (and probably methylation) involves C-3' rather than C-2' in 7-hydroxy-4'-methoxyisoflavone.Whilst the methylations involveS-adenosylmethionine, the hydroxylating enzymes are probably very similar to the flavanone-isoflavone-rearranging enzyme.The closure of ring-B to form finally the rotenoid system probably involves conjugate addition of a methoxyl radical.Prenylation and oxidative modifications are characteristically late-stage processes.