911468-83-2

Upstream product

• 304436-75-7 1-deoxy-1-(2,4-difluorophenyl)-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranose 
• 263701-23-1 1'-deoxy-β-1'-(2,4-difluorophenyl)-D-ribofuranose 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 217300-17-9 chloromethoxy-triisopropyl-silane 
• 911468-85-4 3'-O-acetyl-1-deoxy-1-(2,4-difluorophenyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-β-D-ribofuranose 

Relevant academic research and scientific papers

Steric effects in RNA interference: Probing the influence of nucleobase size and shape

Nonpolar nucleosides with varying size and shape have been used to study the hydrogen-bonding stabilization and steric effects on RNA interference. The uracil and adenine residues of siRNA guide strands have been replaced by nonpolar isosteres of uracil a

The roles of hydrogen bonding and sterics in RNA interference

(Formula Presented) Better than normal: RNA-interference studies with mismatched target RNA have demonstrated sequence selectivity (at the single-nucleotide level) at many different positions of the RNA strand. The use of rF in place of rU at position 7 a