91147-43-2

Basic information

• Product Name: N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine
• Synonyms: N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine;Brimonidine Impurity A;Brimonidine EP Impurity A
• CAS NO: 91147-43-2
• Molecular Formula: C11H11N5
• Molecular Weight: 213.23854
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 91147-43-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 393.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
• PKA: 8.36±0.10(Predicted)
• CAS DataBase Reference: N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine(91147-43-2)
• EPA Substance Registry System: N-(4,5-Dihydro-1H-iMidazol-2-yl)-6-quinoxalinaMine(91147-43-2)

Safety Data

• Hazardous Substances Data: 91147-43-2(Hazardous Substances Data)

Usage

Uses

N-(4,5-Dihydro-1H-imidazol-2-yl)-6-quinoxalinamine is an analogue of Brimonidine (B677520), a α2-Adrenoceptor agonist and antiglaucoma agent.

Upstream product

• 6298-37-9 6-aminoquinoxaline 
• 184367-27-9 tert-butyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate 

Relevant articles and documents

Preparation method of brimonidine debromination impurity

The invention discloses a preparation method of a brimonidine debromination impurity. The preparation method comprises the following steps: with 2-(methylthio)-2-imidazoline hydriodide as a raw material, carrying out tert-butyloxycarbonyl protection on 2-(methylthio)-2-imidazoline hydriodide, and subjecting the protected 2-(methylthio)-2-imidazoline hydriodide to reacting with 6-aminoquinoxaline to obtain the impurity. The preparation method of the brimonidine debromination impurity provided by the invention has the advantages that the raw materials are easy to obtain, an environment-friendlyeffect is realized, and operation is easy. The prepared brimonidine debromination impurity provides an important basis for quality and safety evaluation of brimonidine, and has important significancefor improvement of a synthesis process.