91148-66-2Relevant academic research and scientific papers
Studies on Pyrimidine Derivatives. XXXIV. Substituent Effect on the Reaction of 4-Substituted 2,6-Dimethylpyrimidine 1-Oxides with Acetic Anhydride
Sakamoto, Takao,Yoshizawa, Hiroshi,Kaneda, Soh-ichi,Yamanaka, Hiroshi
, p. 728 - 732 (2007/10/02)
The reaction of 2-methyl- and 4-methylpyrimidine N-oxides with acetic anhydride proceeded smoothly in benzene solution to give 2-acetoxymethyl- and 4-acetoxymethylpyrimidines, respectively.The same reaction of 4-methoxy-2,6-dimethylpyrimidine 1-oxide afforded 2-acetoxymethyl-4-methoxy-6-methylpyrimidine as a sole product.Other examples of such siteselective acetoxylation of pyrimidine N-oxides are also described.Keywords - substituent effect; site-selective reaction; acetoxymethylpyrimidine; active methyl group; pyrimidine N-oxide
