911490-61-4Relevant academic research and scientific papers
Routes to HIV-integrase inhibitors: efficient synthesis of bicyclic pyrimidones by ring expansion or amination at a benzylic position
Ferreira, Maria del Rosario Rico,Cecere, Giuseppe,Pace, Paola,Summa, Vincenzo
scheme or table, p. 148 - 151 (2009/04/14)
Ring expansion of [6,6] bicyclic pyrimidones led, through an aziridinium intermediate, to potent HIV-integrase inhibitors with a [7,6] core. A more flexible and diversity-oriented synthesis of functionalized pyrimidohexahydrodiazepines was then developed;
