91150-50-4

Upstream product

• 930-96-1 3-bromo-2-thiophenecarboxaldehyde 
• 1067-74-9 Methyl diethylphosphonoacetate 

Downstream Products

• 540484-04-6 ((2S,4R)-2-Oxo-2-phenyl-3,4-dihydro-2λ⁶-thieno[3,2-c][1,2]thiazin-4-yl)-acetic acid methyl ester 

Relevant academic research and scientific papers

The intramolecular, stereoselective addition of sulfoximine carbanions to α,β-unsaturated esters

ortho-Bromocinnamates can be coupled with methyl phenylsulfoximine to afford N-arylsulfoximines in excellent yield. Treatment of these products with an amide base results in a completely stereoselective cyclization to afford enantiomerically pure benzothiazines. This reaction is stereospecific.