911626-95-4Relevant academic research and scientific papers
Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction
Surmiak, Ewa,Neochoritis, Constantinos G.,Musielak, Bogdan,Twarda-Clapa, Aleksandra,Kurpiewska, Katarzyna,Dubin, Grzegorz,Camacho, Carlos,Holak, Tad A.,D?mling, Alexander
, p. 384 - 407 (2017)
Using the computational pharmacophore-based ANCHOR.QUERY platform a new scaffold was discovered. Potent compounds evolved inhibiting the protein-protein interaction p53-MDM2. An extensive SAR study was performed based on our four-point pharmacophore model
A novel method for preparing isocyanides from N-substituted formamides with chlorophosphate compounds
Kobayashi, Genki,Saito, Tateo,Kitano, Yoshikazu
experimental part, p. 3225 - 3234 (2011/11/30)
Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl2, EtOPOCl2, Me2NPOCl2, and (PhO)2POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. Georg Thieme Verlag Stuttgart · New York.
Phenyl and pyridyl LTA4H modulators
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Page/Page column 24, (2010/11/24)
Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and inflammatory conditions.
