91168-75-1

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 73893-62-6 2-chloroacetyl-3-(5-methyl-isoxazol-3-ylamino)-acrylic acid ethyl ester 
• 73893-51-3 2-Anilinomethylen-4-chloracetessigsaeure 
• 73893-52-4 4-Chloro-3-oxo-2-[1-(3-trifluoromethyl-phenylamino)-meth-(Z)-ylidene]-butyric acid 
• 137487-60-6 ethyl 3-(chloromethyl)-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Diversity-oriented synthesis of 1-hydroxy-2,4-benzodioates by regioselective [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-alkoxy- and 3-silyloxy-2-alkoxycarbonyl-2-en-1-ones

1-Hydroxy-3,5-dimethyl-2,4-benzodioates (4-hydroxyisophthalates) were prepared by [3+3] cyclocondensation of 1,3-bis(silyloxy)-1,3-butadienes with 3-ethoxycarbonyl-4-trimethylsilyloxy-3-penten-2-one which is synthesized from (symmetrical) ethyl 2-acetylacetoacetate. The [3+3] cyclization of 1,3-bis(silyloxy)-1,3-butadienes with 3-alkoxy-2-alkoxycarbonyl-2-en-1-ones, readily available by reaction of β-ketoesters with trialkyl orthoformiates, provide a convenient and regioselective approach to a great variety of 3-substituted 1-hydroxy-2,4-benzodioates that are not readily available by other methods.

New Pyridine Analogues IX 519

The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

2-piperazinopyrimidine derivatives

The present invention relates to novel 2-piperazinopyrimidine derivatives represented by the following general formula [I] which are useful as, for example, an active ingredient of herbicides STR1 wherein R1 is a hydrogen atom or an aralkyl group and Y is one of the groups represented by the following general formulas [II] to [VII] STR2 (wherein a and b are positions to be bound to positions 4 and 5 of the pyrimidine ring of the formula [I], respectively; l1 and l2 each are an integer of 2 to 4; l3 is 2 or 0; l4 is 0 or 1, provided that l4 is 0 when l3 is 2 and l4 is 1 when l3 is 0; l5 is 2 or 3; l6 is 1 or 2; l7 is 2 or 3; R2 is a hydroxyl group or a toluenesulfonyloxy group; and R3, R4, R5, R6 and R7 each are a hydrogen atom or a lower alkyl group).