91176-30-6Relevant academic research and scientific papers
Reductive Alkylation of Alkenyl Acetates with Alkyl Bromides by Nickel Catalysis
Bai, Yunfei,Han, Guan-Yu,He, Rong-De,Liu, Xue-Yuan,Pan, Xiaobo,Pang, Xiaobo,Shu, Xing-Zhong,Zhao, Zhen-Zhen
supporting information, (2021/12/14)
Catalytic alkylation of stable alkenyl C?O electrophiles is synthetically appealing, but studies to date have typically focused on the reactions with alkyl Grignard reagents. We report herein a cross-electrophile reaction of alkenyl acetates with alkyl bromides. This work has enabled a new method for the synthesis of aliphatic alkenes from alkenyl acetates to be established that can be used to add more structural complexity and molecular diversity with enhanced functionality tolerance. The method allows for a gram-scale reaction and modification of biologically active molecules, and it affords access to useful building blocks. Preliminary mechanistic studies reveal that the NiI species plays an essential role for the success of the coupling of these two reactivity-mismatched electrophiles.
ALKYLATION DE TERPENES EN DEUX ETAPES PAR ENE-REACTION
Deleris, G.,Dunogues, J.,Gadras, A.
, p. 2135 - 2138 (2007/10/02)
A simple, two-step homologation of terpenes is reported that requires ene-reaction with PhSO2NSO and subsequent of the intermediate adducts with CuI catalyzed Grignard
