911790-37-9Relevant academic research and scientific papers
Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors
Chirapu, Srinivas Reddy,Pachaiyappan, Boobalan,Nural, Hikmet F.,Cheng, Xin,Yuan, Hongbin,Lankin, David C.,Abdul-Hay, Samer O.,Thatcher, Gregory R.J.,Shen, Yong,Kozikowski, Alan P.,Petukhov, Pavel A.
body text, p. 264 - 274 (2009/05/26)
A series of transition state analogues of beta-secretases 1 and 2 (BACE1, 2) inhibitors containing fused-ring or biaryl moieties were designed computationally to probe the S2 pocket, synthesized, and tested for BACE1 and BACE2 inhibitory activity. It has
Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof
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Page/Page column 222, (2010/11/24)
The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
