91181-53-2Relevant academic research and scientific papers
Pd-catalyzed intermolecular ortho-C-H amidation of anilides by N-nosyloxycarbamate
Ng, Ka-Ho,Chan, Albert S. C.,Yu, Wing-Yiu
supporting information; experimental part, p. 12862 - 12864 (2010/11/03)
A palladium-catalyzed ortho-C-H amidation of anilides by N-nosyloxycarbamates was developed for the synthesis of 2-aminoanilines. This reaction can be carried out under relatively mild conditions and exhibits excellent regioselectivity and functional group tolerance. The amidation reaction is probably initiated by rate-limiting C-H cyclopalladation (k H/kD = 3.7) to form an arylpalladium complex, followed by nitrene functionalization.
