911828-89-2

Upstream product

• 153501-19-0 ethyl 5-chloro-3-methoxyindole-2-carboxylate 
• 153501-18-9 ethyl 5-chloro-3-hydroxyindole-2-carboxylate 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 21716-60-9 5-Chlor-2-methoxycarbonylmethylamino-benzoesaeuremethylester 

Downstream Products

• 911829-13-5 3-(3,5-bis-trifluoromethyl-phenoxy)-1-(4-tert-butyl-phenyl)-5-chloro-1H-indole-2-carboxylic acid ethyl ester 
• 911828-97-2 1-(4-tert-butyl-phenyl)-5-chloro-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.