911845-45-9

Usage

Uses

Used in Medicinal Chemistry:
(3R,3aS)-7-bromo-3-((1,1-dimethylethyl)dimethylsilanemethyl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-1-one is used as a potential candidate in medicinal chemistry for its unique structural features. The presence of a bromo group and the dimethylsilane group, along with the fused ring system, may contribute to its interaction with biological targets, making it a candidate for the development of new drugs or therapeutic agents.
Used in Materials Science:
In the field of materials science, (3R,3aS)-7-bromo-3-((1,1-dimethylethyl)dimethylsilanemethyl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-1-one may be utilized for its potential to form new materials with specific properties. The combination of the tert-butyl group and the dimethylsilane group could influence the compound's stability, reactivity, or other physical characteristics, which could be harnessed for the creation of advanced materials with applications in various industries.
Further research and analysis would be essential to fully understand the properties and potential uses of (3R,3aS)-7-bromo-3-((1,1-dimethylethyl)dimethylsilanemethyl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-1-one, as its complex structure suggests a wide range of possible applications that are yet to be explored.

Upstream product

• 321-23-3 4-bromo-2-fluoronitrobenzene 

Downstream Products

• 1341208-56-7 N-{[(3S,3aS)-7-(3-nitrophenyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl]methyl}acetamide 
• 1341208-57-8 N-{[(3S,3aS)-7-(4-cyanophenyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl]methyl}acetamide 
• 1341208-59-0 N-{[(3S,3aS)-7-(3-aminophenyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl]methyl}acetamide 
• 1341208-58-9 N-{[(3S,3aS)-7-(4-acetylphenyl)-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl]methyl}acetamide 
• 1341209-33-3 [(3R,3aS)-7-bromo-1-oxo-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin3-yl]methyl 3-nitrobenzene-1-sulfonate 
• 1341208-55-6 N-{[(3S,3aS)-1-oxo-7-phenyl-1,3,3a,4-tetrahydrobenzo[b]oxazolo[3,4-d][1,4]oxazin-3-yl]methyl}acetamide 

Relevant academic research and scientific papers

Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents

A series of novel benzoxazinyl-oxazolidinones bearing nonaromatic heterocycle or aryl groups were designed and synthesized. Their in vitro and in vivo antibacterial activities were investigated. Most of the (3S, 3aS) biaryl benzoxazinyl-oxazolidinones exhibited potent activity against Gram-positive pathogens. SAR trends were observed; a pyridyl C ring was preferable to other 5- or 6-member aryl C rings, while fluorine substitution on the B ring generated derivatives with reduced activity. Various substituent group positions on the pyridyl ring were also evaluated. The resulting compounds displayed excellent activity against linezolid-resistant strains. Compound 45 exhibited excellent in vitro activity, with a MIC value of 0.25-0.5 μg/mL against MRSA and an activity against linezolid-resistant strains of 8-16-fold higher potency than linezolid. In a MRSA systemic infection model, compound 45 displayed an ED 50 5.0 mg/kg, a potency that is nearly 3-fold better than that of linezolid. This compound also showed excellent pharmacokinetic profiles, with a half-life of more than 5 h as well as an oral bioavailability of 81% in rats.