911848-49-2Relevant academic research and scientific papers
Stereochemistry of internucleotide bond formation by the H-phosphonate method. Part 6: Optimization of the reaction conditions towards highest stereoselectivity
Sobkowski, Michal,Stawinski, Jacek,Kraszewski, Adam
, p. 2508 - 2518 (2008)
The condensations of ribonucleoside 3′-H-phosphonates with simple alcohols and nucleosides are known to be stereoselective reactions that favour formation of DP(SP)-diastereomers of the produced H-phosphonate diesters without engagin
Stereochemistry of internucleotide bond formation by the H-phosphonate method. Part 3: Investigations on a mechanism of asymmetric induction
Sobkowski, Michal,Kraszewski, Adam,Stawinski, Jacek
, p. 2336 - 2348 (2008/02/13)
The stereochemistry of H-phosphonate diester bond formation (including internucleotide ones) with ribonucleoside H-phosphonates as substrates has been investigated using 31P NMR spectroscopy. It was found that the reactions investigated owe the
Aryl nucleoside h-phosphonates as a tool for investigation of stereospecificity during coupling
Sobkowski, Michal,Jankowska, Jadwiga,Stawinski, Jacek,Kraszewski, Adam
, p. 887 - 890 (2007/10/03)
It was found that in stereoselective condensations of ribonucleoside 3′-H-phosphonates with alcohols, the major diastereomer of the produced H-phosphonate diesters is formed from the minor diastereomer of the intermediate phosphonic-pivalic anhydride. Copyright Taylor & Francis, Inc.
