911855-77-1

Basic information

• Product Name: 6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine
• Synonyms: 6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine
• CAS NO: 911855-77-1
• Molecular Weight: 839.222
• Mol File: 911855-77-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine(911855-77-1)
• EPA Substance Registry System: 6-[(3R,4R,5S)-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine(911855-77-1)

Safety Data

• Hazardous Substances Data: 911855-77-1(Hazardous Substances Data)

Upstream product

• 911855-71-5 6-[(3R,4R,5S)-4-(4-chloromethyl-phenyl)-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 911855-78-2 (R)-3-methoxy-2-methyl-propan-1-ol 
• 911855-72-6 {4-[(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-4-yl]-phenyl}-methanol 

Relevant articles and documents

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS

The application relates to novel substituted piperidines of the general formula (II) in which R1, R2', R2'', R4', X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.