91203-80-4Relevant academic research and scientific papers
A simple procedure for the deuteriation of phenols
Tuck, Kellie L.,Tan, Hai-Wei,Hayball, Peter J.
, p. 817 - 823 (2000)
A simple procedure for the deuteriation of a large range of phenols has been developed using Amberlyst 15, a polymer supported acid catalyst. A number of phenols present in olive oil have been successfully deuteriated. The aromatic protons of hydroxytyrosol are 100% exchanged under the conditions used. This method is applicable for the tritiation of phenols.
Biosynthesis of Phenanthroindolizidine Alkaloids: Incorporation of 2-Pyrrolidin-2-ylacetophenone and Benzoylacetic Acid and Derivatives
Herbert, Richard B.,Jackson, Frederick B.,Nicolson, Ian T.
, p. 825 - 831 (2007/10/02)
2-Pyrrolidin-2-ylacetophenone (12) and its oxygenated derivatives, (13) and (14), bearing 14C and 3H labels are synthesized and are shown to be intact precursors for the phenanthroindolizidine alkaloid, tylophorinine (16), in Tylophora asthmatica; the three amines, singly labelled with tritium, are shown to be precursors for tylophorine (3) and tylophorinidine (17).Benzoylacetic acid (9) and p-hydroxybenzoylacetic acid (10), but not 4-hydroxy-3-methoxybenzoylacetic acid, are also precursors for tylophorinine (16).The results allow partial description of the biosynthetic pathways tophenanthroindolizidine alkaloids.A degradation is described which allowed the location of label in 2-pyrrolidin-2-ylacetophenone, derived from ornithine, to be established.
