91222-27-4Relevant articles and documents
A general and mild Cu-catalytic: N -arylation of iminodibenzyls and iminostilbenes using unactivated aryl halides
Yao, Wubing,Zhang, Bin,Li, Rongrong,Jiang, Huajiang,Chen, Xiaoying,Li, Fang
, p. 49600 - 49604 (2017)
A ligand-free, highly efficient Cu-catalytic N-arylation of iminodibenzyl and iminostilbene derivatives with a broad scope of unactivated aryl halides under mild conditions has been developed for the first time. Moreover, the first Ni-based catalytic syst
Metal-free late-stage C(sp2)-H functionalization of: N -aryl amines with various sodium salts
Mudithanapelli, Chandrashekar,Kim, Mi-Hyun
, p. 450 - 464 (2020/02/03)
Metal-free consecutive C(sp2)-X (X = Cl, Br, S, N) bond formations of N-aryl amines (cyclic, fused, carbamate, and aminium radicals) were achieved under mild conditions using [bis(trifluoroacetoxy)iodo]benzene (PIFA) and simple nonharmful sodium salts. This direct and selective C(sp2)-H functionalization showed excellent functional group compatibility, cost effectiveness, and late-stage applicability for the synthesis of biologically active natural products. Two mechanisms were proposed to explain the ortho- or para-preference, as well as the accelerating effect of CH3NO2
PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp2)-H or C(sp3)-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water
Mudithanapelli, Chandrashekar,Dhorma, Lama Prema,Kim, Mi-Hyun
supporting information, (2019/05/07)
A novel nitration (via C(sp3)-N breaking/C(sp2)-N formation with CH3NO2) mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp2)-H functionalization can shift to an α-C(sp3)-H functionalization (cyanation or oxygenation) of the α-C(sp3)-H of cyclic amines.
Novel method for nickel-catalyzed imino dibenzyl derivative amination
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Paragraph 0047-0050, (2018/04/01)
The invention relates to a novel method which can smoothly catalyze an organic light emitting diodes (OLEDs) material unit - imino dibenzyl derivative to undergo amination with iodo- or bromo- arene under mild conditions by using a cheap and easily-obtain
New method for amination reaction of organic light emitting diode material under catalysis of copper
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Paragraph 0047-0050, (2018/04/01)
The invention adopts a copper reagent which is cheap and prone to acquire as a catalyst, participation of ligand is not needed, and a common dimethylsulfoxide is used as the solvent, so that an amination reaction between iminodibenzyl ramification, an org
Palladium-Catalyzed N-Arylation of Iminodibenzyls and Iminostilbenes with Aryl- and Heteroaryl Halides
Huang, Wenliang,Buchwald, Stephen L.
supporting information, p. 14186 - 14189 (2016/09/23)
Compounds containing the iminodibenzyl and iminostilbene ring systems are prevalent in medicinal targets and functional materials. Herein, we report palladium-catalyzed conditions for the N-arylation of these ring systems. This protocol could be applied to a variety of (hetero)aryl chloride and bromide substrates, including ones, which are sterically hindered or those containing a variety of functional groups. Use of the fourth-generation palladacycle precatalyst gave good to excellent yields by using low palladium-catalyst loadings (0.1 to 1 mol %).
Buchwald-Hartwig amination of aryl chlorides catalyzed by easily accessible benzimidazolyl phosphine-Pd complexes
Chung, Kin Ho,So, Chau Ming,Wong, Shun Man,Luk, Chi Him,Zhou, Zhongyuan,Lau, Chak Po,Kwong, Fuk Yee
supporting information; experimental part, p. 1181 - 1186 (2012/06/15)
This study describes the efficacy of benzimidazolyl phosphine ligands, which are easily synthesized from inexpensive and commercially available o-phenylenediamine, 2-bormobenzoic acid, and chlorophosphines, in the Buchwald-Hartwig amination of aryl chlorides. Primary and secondary aromatic/aliphatic amines are effective substrates in this catalytic system. Functional groups such as keto and esters are also compatible. The catalyst loading can be reduced to 0.1 mol% Pd. Georg Thieme Verlag Stuttgart · New York.
