912286-46-5

Upstream product

• 912286-41-0 Aminofentanyl 
• 912286-42-1 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide 
• 912286-43-2 2-amino-N-{2-[(1-phenethyl-piperidin-4-yl)-phenyl-carbamoyl]-ethyl}-3-phenyl-propionamide 

Downstream Products

• 912286-47-6 2-amino-N-[(1-{2-[(1-phenethyl-piperidin-4-yl)-phenyl-carbamoyl]-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-propionamide 

Relevant academic research and scientific papers

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity

An enkephalin analogue coupled to 'aminofentanyl' has been synthesized and tested for biological activities at the μ and δ opioid receptors. Aminofentanyl which represents a structural derivative of fentanyl has been synthesized by acylation of 1-(2-phenethyl)-4-(N-anilino)piperidine with phthaloyl protected β-alaninyl chloride in the presence of DIPEA, followed by deprotection with hydrazine hydrate. Aminofentanyl has also been successfully acylated with ethyl isocyanate, various acid anhydrides, to further investigate structure-activity relationships of these new fentanyl derivatives. Among the new derivatives compound 7 which carries a Tyr-d-Ala-Gly-Phe opioid message sequence showed good opioid affinity (1 nM at both δ and μ opioid receptors) and bioactivity (34.9 nM in MVD and 42 nM in GPI/LMMP bioassays).