912337-58-7

Basic information

• Product Name: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid
• Synonyms: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid
• CAS NO: 912337-58-7
• Molecular Weight: 393.439
• Mol File: 912337-58-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid(912337-58-7)
• EPA Substance Registry System: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid(912337-58-7)

Safety Data

• Hazardous Substances Data: 912337-58-7(Hazardous Substances Data)

Upstream product

• 910867-07-1 ethyl (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonamido)pyrimidin-5-yl]acrylate 
• 1024024-26-7 methyl 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoate 

Downstream Products

• 1005003-77-9 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoyl methyl carbonate 
• 910867-08-2 (E)-N-(4-(4-fluorophenyl)-5-(3-hydroxyprop-1-en-1-yl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide 
• 912337-59-8 methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate 

Relevant articles and documents

PROCESS FOR PREPARING ROSUVASTATIN CALCIUM

The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of Formula I which is an intermediate useful in the preparation of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methyl-sulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid] calcium salt of Formula II

PROCESS FOR PREPARATION OF CALCIUM SALT OF ROSUVASTATIN

The invention relates to commercially viable process for the preparation of Rosuvastatin by an early introduction of correct absolute stereochemistry at C-5 (S) of Rosuvastatin side chain followed by regioselective chain extension using novel side chain building blocks and less expensive reagents. It is yet another object of the invention is to provide novel intermediates that may be used for the preparation of Calcium salt of Rosuvastatin.Formula (I).