912342-01-9Relevant academic research and scientific papers
SMALL MOLECULE MODULATORS OF HUMAN STING
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Page/Page column 136; 137, (2019/01/10)
The present invention relates to compounds of formula (I). The compounds maybe used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.
Efficient synthesis of chiral phenethylamines: preparation, asymmetric hydrogenation, and mild deprotection of ene-trifluoroacetamides
Allwein, Shawn P.,McWilliams, J. Christopher,Secord, Elizabeth A.,Mowrey, Dale R.,Nelson, Todd D.,Kress, Michael H.
, p. 6409 - 6412 (2007/10/03)
A mild and efficient route to enantioenriched aryl alkyl amines from ketones has been developed. The first successful synthesis and asymmetric hydrogenation of ene-trifluoroamides from oximes gave highly enantioenriched trifluoroacetamides (94-98% ee). The corresponding phenethyl amides are liberated under mild conditions (K2CO3, MeOH/H2O). In addition, a new application of Josiphos ligands toward the asymmetric hydrogenation of both ene-acetamides and ene-trifluoroacetamides was discovered.
