912342-05-3

Basic information

• Product Name: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-ethyl]-acetamide
• Synonyms: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-ethyl]-acetamide
• CAS NO: 912342-05-3
• Molecular Weight: 277.243
• Mol File: 912342-05-3.mol

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-ethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-ethyl]-acetamide(912342-05-3)
• EPA Substance Registry System: 2,2,2-trifluoro-N-[1-(4-methoxymethoxy-phenyl)-ethyl]-acetamide(912342-05-3)

Safety Data

• Hazardous Substances Data: 912342-05-3(Hazardous Substances Data)

Upstream product

• 161196-99-2 4-(Methoxymethoxy)-1-benzonitrile 
• 85699-00-9 1-[4-(methoxymethoxy)phenyl]-1-ethanone 
• 912341-94-7 1-(4-methoxymethoxy-phenyl)-ethanone oxime 

Relevant articles and documents

Efficient synthesis of chiral phenethylamines: preparation, asymmetric hydrogenation, and mild deprotection of ene-trifluoroacetamides

A mild and efficient route to enantioenriched aryl alkyl amines from ketones has been developed. The first successful synthesis and asymmetric hydrogenation of ene-trifluoroamides from oximes gave highly enantioenriched trifluoroacetamides (94-98% ee). The corresponding phenethyl amides are liberated under mild conditions (K2CO3, MeOH/H2O). In addition, a new application of Josiphos ligands toward the asymmetric hydrogenation of both ene-acetamides and ene-trifluoroacetamides was discovered.