91245-99-7

Usage

Chemical structure

A cyclopropane ring attached to a benzyl group with a methoxy substituent and an amine group.

Functional groups

Amine group (nitrogen atom attached to three carbon atoms) and methoxybenzyl group.

Potential applications

Medicinal chemistry and pharmaceutical research due to the presence of amines, which are important functional groups in drug molecules.

Synthetic utility

The methoxybenzyl group is commonly used as a protective group in organic synthesis to protect alcohols and amines, making 1-(4-methoxybenzyl)cyclopropane-1-amine a potential intermediate in organic reactions.

Versatility

The compound has potential applications in both medicinal and synthetic chemistry due to its unique structure and functional groups.

Stability

Cyclopropane rings are generally less stable than larger carbocyclic rings, so the compound may be sensitive to certain reaction conditions.

Reactivity

The amine group in the compound can participate in various reactions, such as alkylation, acylation, and nucleophilic substitution, making it a versatile building block in organic synthesis.

Solubility

The presence of the methoxy group may increase the compound's solubility in polar solvents, such as water and methanol.

Polarity

The compound is likely to be polar due to the presence of the amine and methoxy groups, which can form hydrogen bonds and interact with other polar molecules.

Biological activity

The compound's specific biological activity is not provided in the material, but the presence of amines and the methoxybenzyl group may contribute to its potential as a pharmacologically active molecule.

Upstream product

• 29765-62-6 1-(4-Methoxy-benzyl)-cyclopropanecarbonyl chloride 
• 29805-88-7 1-(4-Methoxy-benzyl)-cyclopropanecarboxylic acid ethyl ester 
• 29765-47-7 1-(4-methoxy-benzyl)-cyclopropanecarboxylic acid 

Downstream Products

• 869535-95-5 8-benzyloxy-5-{1-hydroxy-2-[1-(4-methoxybenzyl)cyclopropylamino]ethyl}-1H-quinolin-2-one 

Relevant academic research and scientific papers

Substituted cycloalkyl derivatives for the treatment of respiratory diseases

N-(Phenyl-substituted cycloalkyl or cycloalkylmethyl)-phenylethanolamine derivatives (I) (including benzo-heterocyclic analogs) are new. Also new are cyclopropylamine or cyclopropylmethylamine derivative intermediates (II). Phenylethanolamine derivatives of formula (I) (including optical isomers, enantiomer mixtures and racemates) and their salts, solvates and hydrates are new. n : 0 or 1; m : 1-4; X : direct bond, 2-6C alkenylene, -O-Q-, -NH-Q-, -S-Q- or -Q-; Q : 1-6C alkylene; R 1>H; and R 3>hydroxyalkyl or halo; or R 1> + R 2>OCH 2CONH, CH 2CH 2CONH, CH=CHCONH, NHCH 2CONH, SCH 2CONH, OCONH, SCONH, NHCONH or OCH 2SO 2NH (all optionally substituted (os) by 1 or 2 of alkyl, OH or halo); R 3>, R 4>H, OH, halo, 1-6C alkyl, 1-6C haloalkyl, 1-6C hydroxyalkyl, NH 2 or mono- or dialkylamino; R 5> - R 8>H, OR 9>, halo, 1-6C alkyl, 1-6C haloalkyl, 1-6C hydroxyalkyl, 3-6C cycloalkyl, 3-6C hydroxycycloalkyl, CN, NO 2, COR 9>, COOR 9>, CONR 10>R 11>, NR 10>R 11>, NR 10>COR 9>, NR 10>SO 2R 12>, SR 12>, SOR 12>, SO 2R 12>, SO 2NR 10>R 11> or halo; or two vicinal groups R 6> - R 8> together= 2-6C alkylene, 2-6C alkenylene or O-Q-O (all os by 1 or 2 of alkyl, alkoxy, OH or halo); R 9> - R 11>H, alkyl, aryl or arylalkyl; R 12>alkyl, aryl or arylalkyl; unless specified otherwise alkyl moieties have 1-4C and aryl moieties 6-10C. An independent claim is included for cycloalkylamine or cycloalkylalkylamine derivative intermediates of formula (II) as new compounds, provided that m= 1. [Image] [Image] ACTIVITY : Antiinflammatory; antiasthmatic; antiallergic; virucide; antibacterial; fungicide; protozoacide; anthelmintic; cardiant; dermatological; immunosuppressive; tocolytic; antiarrhythmic; vasotropic; antipruritic. MECHANISM OF ACTION : beta -Mimetic.