91254-23-8

Basic information

• Product Name: 7-Chloro-3-hydroxy-1-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
• CAS NO: 91254-23-8
• Molecular Weight: 316.744
• Mol File: 91254-23-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-Chloro-3-hydroxy-1-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-3-hydroxy-1-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(91254-23-8)
• EPA Substance Registry System: 7-Chloro-3-hydroxy-1-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one(91254-23-8)

Safety Data

• Hazardous Substances Data: 91254-23-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 604-75-1 oxazepam 

Relevant articles and documents

Kinetic Isotope Effect in the Metabolic Demethylation of Temazepam

The kinetics of the metabolic demethylation of temazepam were examined.Oxidative cleavage of the 1-methyl C-H bonds is rate-determining in the 13000 g supernatant of mouse liver homogenate, as shown by the primary deuterium isotope effect (3.6) for demethylation of 1-CD3-labelled temazepam.With a reduced supply of NADPH, reduction of the cytochrome P-450-substrate complex becomes rate-limiting.Decomposition of the 1-N-hydroxymethyl intermediate is fast enough not to influence the rate of demethylation.